Cardiovascular disorders are reported to be the leading cause of death. There are numerous grounds of the disorders that are directly related to the environmental and genetic factors of the patients. Each factor has the potential to influence the pathophysiology of patients in a parent that can instigate cardiovascular disorder. The most common observed is atherosclerosis is one such arterial disease that is believed to be directly concerned with the genetics. A number of studies have revealed the interconnection of the genetic factors with the source of the disease. In recent years, the investigation over the spectrum of genes, genetics, polymorphisms and other suspicious loci connected with the kind of disease. The purpose of such an evaluation is to explore the influence of genetics over the development of the disease. Genetics factor such as metabolic syndrome or diabetes are likely to support the development of the disorder. The investigation of atherosclerosis over genetic grounds has revealed the dynamic development of plaque from the infancy. Records mention that 45% of infants with a genetic connection develop the disease up to the age of 8 months and the ratio exceeds to 65% at the bracket of teenage.
Likewise, the added factor of hypertension can further lead to the complication of the alteration if accompanied with the genetics. The combination is likely to cause an injury to the coronary artery endothelial lining, which can be aggravated the risk factors. The element of inflammation is the most evident factor of pathophysiology; the same can be concealed in the patients of hypertension where the medicines have the likelihood to regulate the flow of blood. Thus, it can be concluded that beyond the molecular basis the pathophysiology of the disorder is highly contextual to genetics and behavioral patterns.
Bakran, S. K. (2012). Genetic Susceptibility to Atherosclerosis. Stroke Research and Treatment, 1-5.